| Accession |
PRJCA017635 |
| Title |
A omics study of total transcriptome and intestinal microecology in coronary heart disease |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Coronary artery disease (CAD) is a widespread heart condition caused by atherosclerosis and influences millions of people worldwide. Early detection of CAD is challenging due to the lack of specific biomarkers. The gut microbiota and host-microbiota interactions have been well documented to affect human health. However, investigation that reveals the role of gut microbes in CAD is still limited. This study aims to uncover the synergistic effects of host genes and gut microbes associated with CAD through integrative genomic analyses. We performed amplicon and transcriptomic sequencing on fecal and blood samples from CAD patients and matched controls. By comparing CAD patients with health controls, we found dysregulated gut microbes and host genes associated with CAD. |
| Sample scope |
Multispecies |
| Release date |
2023-06-12 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Alternations in gut microbiota and host transcriptome of patients with coronary artery disease
|
medRXiv
|
10.1101/2023.07.14.23292642
|
2023
|
| 37924005
|
Alterations in gut microbiota and host transcriptome of patients with coronary artery disease
|
BMC Microbiology
|
10.1186/s12866-023-03071-w
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| the Hangzhou Medical and Health Technology Project
|
|
Z20200135
|
|
| the Construction Fund of Key Medical Disciplines of Hangzhou
|
|
OO20200121
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32200535
|
|
| the Scientific Research Foundation for Talents of Wenzhou Medical University
|
|
KYQD20201001
|
|
|
|
| Submitter |
Liuying
Chen (lychen93@163.com)
|
| Organization |
affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine |
| Submission date |
2023-06-10 |
