| 项目编号 |
PRJCA017782 |
| 项目标题 |
Senolytic and senomorphic agent PCC1 alleviates structural and functional decline in aged retina |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
By establishing naturally aging mouse models in the current study, we have revealed the structural and functional decline in the aged retina which accompanied the accumulation of senescent cells and SASP factors. We have further validated the senolytic and senomorphic property of PCC1 both in vitro and in vivo, the long-term treatment of which ameliorated the age-related impairment in retina. Here, we upload the scRNA-seq data of young, aged and PCC1-treated aged retina. |
| 样品范围 |
Single cell |
| 发布日期 |
2024-04-10 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38657052
|
Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina
|
Proceedings of the National Academy of Sciences of the United States of America
|
10.1073/pnas.2311028121
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82171057
|
|
|
|
| 提交者 |
Wenru
Su (suwr3@mail.sysu.edu.cn)
|
| 提交单位 |
Zhongshan Ophthalmic Center,Sun Yat-sen University |
| 提交日期 |
2023-06-19 |
