| Accession |
PRJCA017804 |
| Title |
Molecular subtypes of neuroendocrine carcinomas |
| Relevance |
Medical |
| Data types |
Epigenomics
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
Neuroendocrine carcinomas (NECs) are extremely lethal malignancies that can arise at almost any anatomic site. They are characterized by rapid growth, early metastasis, and significant heterogeneity. To identify determinants of their heterogeneity, we conducted transcriptomic sequencing, transposase-accessible chromatin sequencing, and spatial transcriptomic sequencing on NECs. We revealed the key role of master transcriptional factors in determining the molecular subtypes of NECs. |
| Sample scope |
Multiisolate |
| Release date |
2024-04-20 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38788718
|
Molecular subtypes of neuroendocrine carcinomas: A cross-tissue classification framework based on five transcriptional regulators
|
Cancer Cell
|
10.1016/j.ccell.2024.05.002
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Beijing Municipal Science & Technology
|
|
Z221100007422011
|
|
| Beijing Municipal Science & Technology
|
|
Z191100001119049
|
|
| Chinese Academy of Medical Sciences
|
|
2021-I2M-1-050
|
|
| Chinese Academy of Medical Sciences
|
|
2021-I2M-1-012
|
|
| China Association for Science and Technology
|
|
2019QNRC001
|
|
|
|
| Submitter |
Nan
Sun (sunnan@cicams.ac.cn)
|
| Organization |
Cancer Hospital, Chinese Academy of Medical Sciences |
| Submission date |
2023-06-20 |
