| Accession |
PRJCA017828 |
| Title |
cfDNA fragmentation is a stepwise and conserved process |
| Relevance |
Medical |
| Data types |
Whole genome sequencing
|
| Organisms |
Mus musculus
Homo sapiens
|
| Description |
Circulating cell-free DNA (cfDNA) is a pool of short DNA fragments mainly released from apoptotic hematopoietic cells. Nevertheless, the precise physiological process governing the DNA fragmentation and molecular profile of cfDNA remains obscure. To dissect the DNA fragmentation process, we use a human leukemia cell line HL60 undergoing apoptosis to analyze the size distribution of DNA fragments by shallow whole-genome sequencing (sWGS). Meanwhile, we also scrutinize the size profile of plasma cfDNA in 901 healthy human subjects and 38 dogs, as well as 438 patients with six common cancer types by sWGS. |
| Sample scope |
Multiisolate |
| Release date |
2023-10-23 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Shenzhen SeekIn Inc.
|
|
NA
|
|
|
|
| Submitter |
Mao
Mao (maomao@seekin.onaliyun.com)
|
| Organization |
Shenzhen SeekIn Inc |
| Submission date |
2023-06-21 |
