| 项目编号 |
PRJCA018003 |
| 项目标题 |
Plasma metabolic signatures uncover therapeutic response and prognosis of third-generation EGFR-TKI treatment in patients with NSCLC |
| 涉及领域 |
Medical |
| 数据类型 |
Metagenomic assembly
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Advanced EGFR T790M-mutated non-small cell lung cancer (NSCLC) inevitably develops resistance to third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) therapy. Metabolic reprogramming support EGFR-TKI resistance, while thorough metabolomics clinical studies are limited. Here, we enrolled 186 NSCLC patients from Phase I and IIa clinical studies and characterized responsive metabolic features of third-generation EGFR-TKI. Our study included locally advanced or metastatic NSCLC patients from the open-label, single-arm, phase I/IIa study of BPI-7711(NCT03386955). Tumor diagnosis was confirmed by histology or cytology, with EGFR-sensitive mutations (including Exon19Deletion, L858R, G719X, L861QandS768I). Patients from phase I study were required to have disease progression after first or second-line EGFR-TKI treatment with T790M resistant mutation while phaseII patients were naive to TKI treatment. Two hundred and twenty plasma samples of 186 patients were collected in 16 hospitals (220 for metabolism,49 for WES and 14 for proteomics). |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-07-04 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Plasma metabolomics profiling of EGFR-mutant NSCLC patients treated with third-generation EGFR-TKI
|
Scientific Data
|
10.1038/s41597-024-04169-0
|
2024
|
| 39680603
|
Spop deficiency impairs adipogenesis and promotes thermogenic capacity in mice
|
PLoS Genetics
|
10.1371/journal.pgen.1011514
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81972805
|
Establishment of multi-omics predictive model of EGFR-TKI efficacy for lung cancer and the molecular regulatory mechanism
|
| Major Project of Medical Oncology Key Foundation of Cancer Hospital Chinese Academy of Medical Sciences
|
General Program
|
CICAMS-MOMP2022006
|
Study of autoantibodies related to the efficacy of third-generation EGFR-TKI
|
|
|
| 提交者 |
Yuankai
Shi (syuankaipumc@126.com)
|
| 提交单位 |
National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences |
| 提交日期 |
2023-06-29 |
