| Accession |
PRJCA018003 |
| Title |
Plasma metabolic signatures uncover therapeutic response and prognosis of third-generation EGFR-TKI treatment in patients with NSCLC |
| Relevance |
Medical |
| Data types |
Metagenomic assembly
|
| Organisms |
Homo sapiens
|
| Description |
Advanced EGFR T790M-mutated non-small cell lung cancer (NSCLC) inevitably develops resistance to third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) therapy. Metabolic reprogramming support EGFR-TKI resistance, while thorough metabolomics clinical studies are limited. Here, we enrolled 186 NSCLC patients from Phase I and IIa clinical studies and characterized responsive metabolic features of third-generation EGFR-TKI. Our study included locally advanced or metastatic NSCLC patients from the open-label, single-arm, phase I/IIa study of BPI-7711(NCT03386955). Tumor diagnosis was confirmed by histology or cytology, with EGFR-sensitive mutations (including Exon19Deletion, L858R, G719X, L861QandS768I). Patients from phase I study were required to have disease progression after first or second-line EGFR-TKI treatment with T790M resistant mutation while phaseII patients were naive to TKI treatment. Two hundred and twenty plasma samples of 186 patients were collected in 16 hospitals (220 for metabolism,49 for WES and 14 for proteomics). |
| Sample scope |
Multiisolate |
| Release date |
2023-07-04 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81972805
|
Establishment of multi-omics predictive model of EGFR-TKI efficacy for lung cancer and the molecular regulatory mechanism
|
| Major Project of Medical Oncology Key Foundation of Cancer Hospital Chinese Academy of Medical Sciences
|
General Program
|
CICAMS-MOMP2022006
|
Study of autoantibodies related to the efficacy of third-generation EGFR-TKI
|
|
|
| Submitter |
Yuankai
Shi (syuankaipumc@126.com)
|
| Organization |
National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences |
| Submission date |
2023-06-29 |
