| Description |
We have identified a novel stem cell type from the costal cartilage of fetal or neonatal mice - termed "Eve cell" - which exhibits multipotency in both osteogenesis and haematopoiesis. Single-cell transcriptional profiling of the Eve cells revealed a distinct transcriptomic signature, along with unique markers compared to other osteogenic and haematopoietic precursor cells. The Eve cells demonstrated osteogenic, chondrogenic, lipogenic, fibrogenic and myogenic differentiation abilities in vitro. Furthermore, Eve cells grown in suspension culture generated a highly proliferative cell clone exhibiting haematopoietic phenotypes. Transplantation of Eve cells into the bone marrow of mice reconstituted the haematopoietic system and led to significant skeletal recovery. In adult mice, reactivated Eve cells also participate in acute phase events, such as fracture or hemorrhage. |
