| 项目编号 |
PRJCA018431 |
| 项目标题 |
The single-cell transcriptome analysis of decidual cells from obstetric antiphospholipid syndrome patients |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by vascular thrombosis and/or pregnancy morbidity associated with persistent antiphospholipid antibody positivity. Cases meet the Sydney criteria for obstetric morbidity with no previous thrombosis are known as obstetric antiphospholipid syndrome (OAPS). OAPS is one of the important identified causes of recurrent pregnancy loss and late-pregnancy morbidity related to placental injury. However, the pathogenesis of OAPS remains unknow. To explore the transcriptome features of decidual cells and intercellular interactions, the first-trimester decidua tissues were collected from five OAPS patients and five healthy controls for single-cell RNA sequencing and subsequent bioinformatic analyses. |
| 样品范围 |
Single cell |
| 发布日期 |
2023-12-30 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38331588
|
Single-cell transcriptome analyses reveal disturbed decidual homoeostasis in obstetric antiphospholipid syndrome
|
Annals of the Rheumatic Diseases
|
10.1136/ard-2023-224930
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| West China Hospital, Sichuan University
|
|
ZYGC18003
|
|
| West China Hospital, Sichuan University
|
|
ZYJC18024
|
|
| West China Hospital, Sichuan University
|
|
ZYGD18015
|
|
|
|
| 提交者 |
Yi
Liu (yi2006liu@163.com)
|
| 提交单位 |
West China Hospital of Sichuan University |
| 提交日期 |
2022-10-08 |
