| Accession |
PRJCA018431 |
| Title |
The single-cell transcriptome analysis of decidual cells from obstetric antiphospholipid syndrome patients |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by vascular thrombosis and/or pregnancy morbidity associated with persistent antiphospholipid antibody positivity. Cases meet the Sydney criteria for obstetric morbidity with no previous thrombosis are known as obstetric antiphospholipid syndrome (OAPS). OAPS is one of the important identified causes of recurrent pregnancy loss and late-pregnancy morbidity related to placental injury. However, the pathogenesis of OAPS remains unknow. To explore the transcriptome features of decidual cells and intercellular interactions, the first-trimester decidua tissues were collected from five OAPS patients and five healthy controls for single-cell RNA sequencing and subsequent bioinformatic analyses. |
| Sample scope |
Single cell |
| Release date |
2023-12-30 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38331588
|
Single-cell transcriptome analyses reveal disturbed decidual homoeostasis in obstetric antiphospholipid syndrome
|
Annals of the Rheumatic Diseases
|
10.1136/ard-2023-224930
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| West China Hospital, Sichuan University
|
|
ZYGC18003
|
|
| West China Hospital, Sichuan University
|
|
ZYJC18024
|
|
| West China Hospital, Sichuan University
|
|
ZYGD18015
|
|
|
|
| Submitter |
Yi
Liu (yi2006liu@163.com)
|
| Organization |
West China Hospital of Sichuan University |
| Submission date |
2022-10-08 |
