| 项目编号 |
PRJCA018456 |
| 项目标题 |
Tryptophan Metabolite Norharman Secreted by Cultivated Lactobacillus Attenuates Acute Pancreatitis as an Antagonist of Histone Deacetylases |
| 涉及领域 |
Medical |
| 数据类型 |
Raw sequence reads
|
| 物种名称 |
Mus musculus
Rattus
Bacteria
|
| 描述信息 |
Patients with acute pancreatitis (AP) exhibit specific phenotypes of gut microbiota associated with severity. Gut microbiota and host interact primarily through metabolites, regrettably, little is known about their roles in AP biological networks. This study examines how enterobacterial metabolites modulate the innate immune system in AP aggravation. lipid metabolomics further confirmed the imbalance of lipid metabolism in macrophages after Rftn1 knockdown, and norharman treatment. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2023-07-19 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 37635216
|
Tryptophan metabolite norharman secreted by cultivated Lactobacillus attenuates acute pancreatitis as an antagonist of histone deacetylases
|
BMC Medicine
|
10.1186/s12916-023-02997-2
|
2023
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
No.2018YFE0195200
|
|
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
No.82004023
|
|
| National Natural Science Foundation of China (NSFC)
|
Major Program
|
No.81873156
|
|
|
|
| 提交者 |
Qi
Zhou (zhouqi94711@163.com)
|
| 提交单位 |
Dalian Medical University |
| 提交日期 |
2023-07-19 |
