| Accession |
PRJCA018456 |
| Title |
Tryptophan Metabolite Norharman Secreted by Cultivated Lactobacillus Attenuates Acute Pancreatitis as an Antagonist of Histone Deacetylases |
| Relevance |
Medical |
| Data types |
Raw sequence reads
|
| Organisms |
Mus musculus
Rattus
Bacteria
|
| Description |
Patients with acute pancreatitis (AP) exhibit specific phenotypes of gut microbiota associated with severity. Gut microbiota and host interact primarily through metabolites, regrettably, little is known about their roles in AP biological networks. This study examines how enterobacterial metabolites modulate the innate immune system in AP aggravation. lipid metabolomics further confirmed the imbalance of lipid metabolism in macrophages after Rftn1 knockdown, and norharman treatment. |
| Sample scope |
Monoisolate |
| Release date |
2023-07-19 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 37635216
|
Tryptophan metabolite norharman secreted by cultivated Lactobacillus attenuates acute pancreatitis as an antagonist of histone deacetylases
|
BMC Medicine
|
10.1186/s12916-023-02997-2
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
No.2018YFE0195200
|
|
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
No.82004023
|
|
| National Natural Science Foundation of China (NSFC)
|
Major Program
|
No.81873156
|
|
|
|
| Submitter |
Qi
Zhou (zhouqi94711@163.com)
|
| Organization |
Dalian Medical University |
| Submission date |
2023-07-19 |
