| 项目编号 |
PRJCA018599 |
| 项目标题 |
Study on the application value of whole-genome sequencing in the evolution, transmission and treatment outcome of drug-resistant Mycobacterium tuberculosis strains |
| 涉及领域 |
Medical |
| 数据类型 |
Whole genome sequencing
Raw sequence reads
|
| 物种名称 |
Mycobacterium tuberculosis
|
| 描述信息 |
In recent years, based on genomic DNA, the whole-genome sequencing technology (WGS) integrated with computer technology has provided a comprehensive description of the genomic characteristics of drug-resistant strains of Mycobacterium tuberculosis. This has filled the research gaps in the evolution and transmission of drug-resistant tuberculosis, as well as the mechanisms of resistance to traditional and new anti-tuberculosis drugs. It has laid a solid technological foundation for the comprehensive, accurate, and integrated determination of the evolution, transmission and drug resistance of Mycobacterium tuberculosis. Therefore, the application of WGS technology in the local area for the study of drug-resistant pulmonary tuberculosis transmission and treatment holds significant clinical and public health importance. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-10-27 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41053587
|
Characteristics of compensatory mutations in rifampicin-resistant tuberculosis and their association with compensated transmission in Ningbo, China
|
BMC Microbiology
|
10.1186/s12866-025-04390-w
|
2025
|
| 38384306
|
Transmission dynamics of drug-resistant tuberculosis in Ningbo, China: an epidemiological and genomic analysis
|
Frontiers in Cellular and Infection Microbiology
|
10.3389/fcimb.2024.1327477
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Department of Science and Technology of Zhejiang Province
|
Zhejiang Provincial Basic Public Welfare Research Program Project of China
|
LTGY23H190001
|
|
| Department of Science and Technology of Zhejiang Province
|
Zhejiang Provincial Basic Public Welfare Research Program Project of China
|
LTGY23H190002
|
|
|
|
| 提交者 |
Yang
Che (13805876046@163.com)
|
| 提交单位 |
Ningbo Municipal Center for Disease Control and Prevention |
| 提交日期 |
2023-07-26 |
