| Accession |
PRJCA018622 |
| Title |
A comprehensive preimplantation genetic testing approach for SEA-type α-thalassemia |
| Relevance |
Medical |
| Data types |
Phenotype or Genotype
|
| Organisms |
Homo sapiens
|
| Description |
The study reports a comprenhensive PGT appoarch for SEA-type α-thalassemia by fluorescent Gap-PCR combined with SNP array. A total of 26 biopsy cycles and 172 embryos were involved in this study. By comparing the consistency of the two test results, we verified the feasibility and necessity of this comprehensive appoarch. This appoarch combines the direct detection of the target genes and haplotype analysis to minimize the risk of misdiagnosis caused by ADO and gene recombination. Moreover, no additonal experimental operation was needed for aneuploidy screening. |
| Sample scope |
Multiisolate |
| Release date |
2023-07-27 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38075678
|
A comprehensive preimplantation genetic testing approach for SEA-type α-thalassemia by fluorescent gap-polymerase chain reaction combined with haplotype analysis
|
Frontiers in Genetics
|
10.3389/fgene.2023.1248358
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82071716
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81771588
|
|
| National Key Research and Development Program of China
|
|
2018YFC1003102
|
|
| Guangzhou Science and Technology Project
|
|
201804020087
|
|
|
|
| Submitter |
Yanwen
Xu (xuyanwen@mail.sysu.edu.cn)
|
| Organization |
The First Affiliated Hospital of Sun Yat-sen University |
| Submission date |
2023-07-27 |
