| 项目编号 |
PRJCA018622 |
| 项目标题 |
A comprehensive preimplantation genetic testing approach for SEA-type α-thalassemia |
| 涉及领域 |
Medical |
| 数据类型 |
Phenotype or Genotype
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
The study reports a comprenhensive PGT appoarch for SEA-type α-thalassemia by fluorescent Gap-PCR combined with SNP array. A total of 26 biopsy cycles and 172 embryos were involved in this study. By comparing the consistency of the two test results, we verified the feasibility and necessity of this comprehensive appoarch. This appoarch combines the direct detection of the target genes and haplotype analysis to minimize the risk of misdiagnosis caused by ADO and gene recombination. Moreover, no additonal experimental operation was needed for aneuploidy screening. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-07-27 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38075678
|
A comprehensive preimplantation genetic testing approach for SEA-type α-thalassemia by fluorescent gap-polymerase chain reaction combined with haplotype analysis
|
Frontiers in Genetics
|
10.3389/fgene.2023.1248358
|
2023
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82071716
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81771588
|
|
| National Key Research and Development Program of China
|
|
2018YFC1003102
|
|
| Guangzhou Science and Technology Project
|
|
201804020087
|
|
|
|
| 提交者 |
Yanwen
Xu (xuyanwen@mail.sysu.edu.cn)
|
| 提交单位 |
The First Affiliated Hospital of Sun Yat-sen University |
| 提交日期 |
2023-07-27 |
