| Accession | PRJCA018714 | ||||||||
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| Title | Study on the key mechanism of retinal degeneration specific immune microenvironment regulating the differentiation and function of retinal neural stem cells after transplantation | ||||||||
| Relevance | Medical | ||||||||
| Data types |
Whole genome sequencing
Transcriptome or Gene expression Single cell sequencing Proteomics/Flow cytometry data/Clinical data |
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| Organisms |
Mus musculus
Homo sapiens |
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| Description | Based on clinical sample data, this study systematically screened the key immune regulatory targets of retinal degenerative diseases, clarifying the immune molecular regulatory mechanism that determines the differentiation process of retinal neuroprecursor cells in the pathological immune microenvironment. At the same time, this study constructed an "immune privilege" and immune molecular regulatory system based on optimizing the directed differentiation and function maintenance of neuroprecursor cells. Multilevel models were applied for validation and large animal preclinical studies were conducted. | ||||||||
| Sample scope | Multispecies | ||||||||
| Release date | 2023-09-13 | ||||||||
| Grants |
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| Submitter | Yuan Gao (gaoyuan8785@126.com) | ||||||||
| Organization | Third Military Medical University(Army Medical University) | ||||||||
| Submission date | 2023-04-14 |
| Resource name | Description |
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