| 项目编号 |
PRJCA018899 |
| 项目标题 |
Succinylation Dynamics in Erythropoiesis |
| 涉及领域 |
Medical |
| 数据类型 |
Proteomics
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Lysine succinylation has emerged as a recently discovered protein modification that significantly impacts the chemical environment and exhibits diverse functions in various biological processes. However, the precise role of lysine succinylation in erythropoiesis remains to be fully elucidated. In this study, we evaluated succinylation levels during erythroid differentiation. We investigated the role of succinylation in erythropoiesis and found that decreased succinylation levels disrupt cell proliferation and differentiation, leading to apoptosis. Through mass spectrometry analysis, we identified a comprehensive list of succinylated proteins in early-stage and late-stage of terminal erythroid cells, uncovering the molecular mechanisms of succinylation regulation in erythropoiesis |
| 样品范围 |
Monoisolate |
| 发布日期 |
2023-08-08 |
| 出版信息 |
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
81920108004
|
|
|
|
| 提交者 |
Han
Gong (hangong@csu.edu.cn)
|
| 提交单位 |
Xiangya Hospital Central South University |
| 提交日期 |
2023-08-08 |
