Accession PRJCA018944
Title Multiomics analysis reveals novel biomarkers in the mouse model of pulmonary tuberculosis
Relevance Medical
Data types Transcriptome or Gene expression
代谢组和蛋白组
Organisms Mus musculus
Description Sequencing of transcriptome, proteome and metabolome were performed on TB mouse model. Differentially expressed genes (DEGs), differentially expressed proteins (DEPs), and differentially expressed metabolites (DEMs) were identified between TB mouse and control ones. Candidate key genes and proteins involved in TB were obtained by overlapping DEGs with DEPs. Candidate key metabolites were selected by calculating the correlations between DEGs and DEMs. Key metabolites were identified by calculating the correlations between candidate key proteins and candidate key metabolites. Pathway analysis of key metabolites were performed using the MetaboAnalyst online tool. Furthermore, key metabolites were used to construct the diagnostic random forest model.
Sample scope Multiisolate
Release date 2024-01-11
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 31770148
Submitter Hongtai Zhang (hongtaizhang@aliyun.com)
Organization Institute of Biophysics, Chinese Academy of Sciences
Submission date 2023-08-10

Project Data

Resource name Description