| 项目编号 |
PRJCA019021 |
| 项目标题 |
mouse mtDNA mutations during aging |
| 涉及领域 |
Medical |
| 数据类型 |
Genome sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
To study the mtDNA mutations of male mouse intestine during aging, we used polymerase gamma (POLG) mutator mice and wild-type mice, and constructed male mice with four theoretically increasing levels of mtDNA mutations: negligible (WT/WT), low (WT/WT*), moderate (WT/Mut**) and high (Mut/Mut***). We seuqenced mtDNA of male mouse intestine at 3, 8 and 12 months. We also sequenced mtDNA of WT male mouse intestine at 20 months, and mtDNA of WT male mouse brain and liver at 3 and 8 months. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-11-21 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38228611
|
NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations
|
Nature Communications
|
10.1038/s41467-024-44808-z
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Key Research and Development Program of China
|
|
2022YFA1103800
|
|
| National Natural Science Foundation projects of China
|
|
92157202
|
|
|
|
| 提交者 |
Liang
Yang (yang_liang@gibh.ac.cn)
|
| 提交单位 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
| 提交日期 |
2023-08-14 |
