| Accession |
PRJCA019021 |
| Title |
mouse mtDNA mutations during aging |
| Relevance |
Medical |
| Data types |
Genome sequencing
|
| Organisms |
Mus musculus
|
| Description |
To study the mtDNA mutations of male mouse intestine during aging, we used polymerase gamma (POLG) mutator mice and wild-type mice, and constructed male mice with four theoretically increasing levels of mtDNA mutations: negligible (WT/WT), low (WT/WT*), moderate (WT/Mut**) and high (Mut/Mut***). We seuqenced mtDNA of male mouse intestine at 3, 8 and 12 months. We also sequenced mtDNA of WT male mouse intestine at 20 months, and mtDNA of WT male mouse brain and liver at 3 and 8 months. |
| Sample scope |
Multiisolate |
| Release date |
2023-11-21 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38228611
|
NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations
|
Nature Communications
|
10.1038/s41467-024-44808-z
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Key Research and Development Program of China
|
|
2022YFA1103800
|
|
| National Natural Science Foundation projects of China
|
|
92157202
|
|
|
|
| Submitter |
Liang
Yang (yang_liang@gibh.ac.cn)
|
| Organization |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
| Submission date |
2023-08-14 |
