| Accession |
PRJCA019036 |
| Title |
Mouse intestinal aging caused by mitochondrial DNA mutations |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
Mus
|
| Description |
Using polymerase gamma (POLG) mutator mice and wild-type mice, we constructed male mice with increasing levels of mtDNA mutations: negligible (WT/WT), low (WT/WT*), moderate (WT/Mut**) and high (Mut/Mut***), and performed RNA sequencing (RNA-seq) of small intestine in WT/WT*, WT/Mut** and Mut/Mut*** male mice. |
| Sample scope |
Multiisolate |
| Release date |
2023-11-21 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38228611
|
NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations
|
Nature Communications
|
10.1038/s41467-024-44808-z
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Key Research and Development Program of China
|
|
2022YFA1103800
|
|
| National Natural Science Foundation projects of China
|
|
92157202
|
|
|
|
| Submitter |
Liang
Yang (yang_liang@gibh.ac.cn)
|
| Organization |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
| Submission date |
2023-08-14 |
