| 项目编号 | PRJCA019308 | ||||||||||
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| 项目标题 | Dissecting the resistance to bevacizumab-based therapy from longitudinal sequencing of colorectal liver metastases | ||||||||||
| 涉及领域 | Medical | ||||||||||
| 数据类型 |
Whole genome sequencing
Transcriptome or Gene expression |
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| 物种名称 | Homo sapiens | ||||||||||
| 描述信息 | Our team focused on the CRLM population receiving BVZ combined with chemotherapy as the first-line standard treatment, and initially explored the precision treatment of tumor resistance based on the genome and transcriptome sequencing of 49 matched samples obtained from multi-time nodes before and after treatment. Meanwhile, we demonstrate the underlying mechanisms of primary drug resistance mediated by SMAD4R361H missense mutations and secondary drug resistance under hepatocyte/myeloid cell interaction, which provided an analytical template and practical clinical basis for the accurate stratification as well as novel combined strategies of the first-line treatment in CRLM. | ||||||||||
| 样品范围 | Multiisolate | ||||||||||
| 发布日期 | 2024-06-07 | ||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | Wangjun Liao (liaowj@smu.edu.cn) | ||||||||||
| 提交单位 | Nanfang Hospital, Southern Medical University | ||||||||||
| 提交日期 | 2023-08-25 |
| 资源名称 | 描述 |
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| BioSample (261) show | - |