项目编号

PRJCA019658

项目标题

Spatial transcriptome of the mouse cloaca

涉及领域

Model organism

数据类型

Transcriptome or Gene expression
Raw sequence reads

物种名称

Mus musculus

描述信息

Evolutionary and functional significance of the mammalian urinary bladder remains undervalued and ill-defined. Here, to determine the molecular architecture of the mouse cloaca, we collected mouse E11.5 embryo and profiled the spatial transcriptome using Geo-seq. Spatial transcriptomics reveal that Wnt2 is expressed in the triangular cloacal mesenchyme domain flanked by the umbilical arteries. Wnt2 is downregulated in Shh mutants, and knockout of Wnt2 causes reduced bladder size and single umbilical artery phenotypes. These findings collectively suggest that the Shh-Wnt2 pathway orchestrates co-development of the bladder and umbilical arteries.

样品范围

Monoisolate

发布日期

2023-09-21

实验材料提供者

Cedars-Sinai Medical Center, Prof Xue Li's lab

项目资金来源

机构	项目类型	授权项目ID
Ministry of Science and Technology of the People's Republic of China (MOST)	National Basic Research Program of China (973 Program)	2019YFA0801402
National Natural Science Foundation of China (NSFC)	Key Program	32130030
Chinese Academy of Sciences (CAS)	Strategic Priority Research Program of Chinese Academy of Sciences (CAS)	XDA16020501

提交者

Xianfa Yang (yxianfa@gmail.com)

提交单位

Guangzhou National Laboratory

提交日期

2023-09-10

项目包含数据信息

资源名称	描述
BioSample (90) show	-
SAMC3175658	RNA-seq of cloaca
SAMC3175657	RNA-seq of cloaca
SAMC3175656	RNA-seq of cloaca
SAMC3175655	RNA-seq of cloaca
SAMC3175654	RNA-seq of cloaca
SAMC3175653	RNA-seq of cloaca
SAMC3175652	RNA-seq of cloaca
SAMC3175651	RNA-seq of cloaca
SAMC3175650	RNA-seq of cloaca
SAMC3175649	RNA-seq of cloaca
SAMC3175648	RNA-seq of cloaca
SAMC3175647	RNA-seq of cloaca
SAMC3175646	RNA-seq of cloaca
SAMC3175645	RNA-seq of cloaca
SAMC3175644	RNA-seq of cloaca
SAMC3175643	RNA-seq of cloaca
SAMC3175642	RNA-seq of cloaca
SAMC3175641	RNA-seq of cloaca
SAMC3175640	RNA-seq of cloaca
SAMC3175639	RNA-seq of cloaca
SAMC3175638	RNA-seq of cloaca
SAMC3175637	RNA-seq of cloaca
SAMC3175636	RNA-seq of cloaca
SAMC3175635	RNA-seq of cloaca
SAMC3175634	RNA-seq of cloaca
SAMC3175633	RNA-seq of cloaca
SAMC3175632	RNA-seq of cloaca
SAMC3175631	RNA-seq of cloaca
SAMC3175630	RNA-seq of cloaca
SAMC3175629	RNA-seq of cloaca
SAMC3175628	RNA-seq of cloaca
SAMC3175627	RNA-seq of cloaca
SAMC3175626	RNA-seq of cloaca
SAMC3175625	RNA-seq of cloaca
SAMC3175624	RNA-seq of cloaca
SAMC3175623	RNA-seq of cloaca
SAMC3175622	RNA-seq of cloaca
SAMC3175621	RNA-seq of cloaca
SAMC3175620	RNA-seq of cloaca
SAMC3175619	RNA-seq of cloaca
SAMC3175618	RNA-seq of cloaca
SAMC3175617	RNA-seq of cloaca
SAMC3175616	RNA-seq of cloaca
SAMC3175615	RNA-seq of cloaca
SAMC3175614	RNA-seq of cloaca
SAMC3175613	RNA-seq of cloaca
SAMC3175612	RNA-seq of cloaca
SAMC3175611	RNA-seq of cloaca
SAMC3175610	RNA-seq of cloaca
SAMC3175609	RNA-seq of cloaca
SAMC3175608	RNA-seq of cloaca
SAMC3175607	RNA-seq of cloaca
SAMC3175606	RNA-seq of cloaca
SAMC3175605	RNA-seq of cloaca
SAMC3175604	RNA-seq of cloaca
SAMC3175603	RNA-seq of cloaca
SAMC3175602	RNA-seq of cloaca
SAMC3175601	RNA-seq of cloaca
SAMC3175600	RNA-seq of cloaca
SAMC3175599	RNA-seq of cloaca
SAMC3175598	RNA-seq of cloaca
SAMC3175597	RNA-seq of cloaca
SAMC3175596	RNA-seq of cloaca
SAMC3175595	RNA-seq of cloaca
SAMC3175594	RNA-seq of cloaca
SAMC3175593	RNA-seq of cloaca
SAMC3175592	RNA-seq of cloaca
SAMC3175591	RNA-seq of cloaca
SAMC3175590	RNA-seq of cloaca
SAMC3175589	RNA-seq of cloaca
SAMC3175588	RNA-seq of cloaca
SAMC3175587	RNA-seq of cloaca
SAMC3175586	RNA-seq of cloaca
SAMC3175585	RNA-seq of cloaca
SAMC3057519	CM4-Rep2
SAMC3057518	CM4-Rep1
SAMC3057517	CM3-Rep2
SAMC3057516	CM3-Rep1
SAMC3057515	CM2-Rep2
SAMC3057514	CM2-Rep1
SAMC3057513	CM1-Rep2
SAMC3057512	CM1-Rep1
SAMC3057511	CE4-Rep2
SAMC3057510	CE4-Rep1
SAMC3057509	CE3-Rep2
SAMC3057508	CE3-Rep1
SAMC3057507	CE2-Rep2
SAMC3057506	CE2-Rep1
SAMC3057505	CE1-Rep2
SAMC3057504	CE1-Rep1
GSA (2)	-
CRA013517	Spatial transcriptomics of the cloaca-2
CRA012566	Geo-seq of the mouse cloaca