| 项目编号 |
PRJCA019698 |
| 项目标题 |
Unraveling the Significance of MET Focal Amplification in Lung Cancer: Integrative NGS, FISH, and IHC Investigation |
| 涉及领域 |
Medical |
| 数据类型 |
Variation
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
A total of 231 NSCLC cases were included for MET amplification/overexpression determination using three methods: FISH, NGS, and IHC. A thorough comparison was performed between these methodologies. The clinical relevance of these approaches in predicting the efficacy of MET inhibitors was evaluated. Additionally, NGS data from 22,010 lung cancer cases in the LAVA database was utilized to examine the biological characteristics of different METamp subtypes. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-03-03 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38369190
|
Unraveling the Significance of MET Focal Amplification in Lung Cancer: Integrative NGS, FISH, and IHC Investigation
|
Modern Pathology
|
10.1016/j.modpat.2024.100451
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82003154
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82372669
|
|
| Shanghai Municipal Health Commission Clinical Research Project
|
|
20194Y0053
|
|
| Shanghai Jiao Tong University Interdisciplinary Program
|
|
YG2019QNA50
|
|
| Shanghai Chest Hospital Nurture Projects for Basic Research
|
|
2020YNJCM02
|
|
|
|
| 提交者 |
Yuchen
Han (ychan@cmu.edu.cn)
|
| 提交单位 |
Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine |
| 提交日期 |
2023-09-11 |
