| Accession |
PRJCA019698 |
| Title |
Unraveling the Significance of MET Focal Amplification in Lung Cancer: Integrative NGS, FISH, and IHC Investigation |
| Relevance |
Medical |
| Data types |
Variation
|
| Organisms |
Homo sapiens
|
| Description |
A total of 231 NSCLC cases were included for MET amplification/overexpression determination using three methods: FISH, NGS, and IHC. A thorough comparison was performed between these methodologies. The clinical relevance of these approaches in predicting the efficacy of MET inhibitors was evaluated. Additionally, NGS data from 22,010 lung cancer cases in the LAVA database was utilized to examine the biological characteristics of different METamp subtypes. |
| Sample scope |
Multiisolate |
| Release date |
2024-03-03 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38369190
|
Unraveling the Significance of MET Focal Amplification in Lung Cancer: Integrative NGS, FISH, and IHC Investigation
|
Modern Pathology
|
10.1016/j.modpat.2024.100451
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82003154
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82372669
|
|
| Shanghai Municipal Health Commission Clinical Research Project
|
|
20194Y0053
|
|
| Shanghai Jiao Tong University Interdisciplinary Program
|
|
YG2019QNA50
|
|
| Shanghai Chest Hospital Nurture Projects for Basic Research
|
|
2020YNJCM02
|
|
|
|
| Submitter |
Yuchen
Han (ychan@cmu.edu.cn)
|
| Organization |
Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine |
| Submission date |
2023-09-11 |
