| 项目编号 |
PRJCA019735 |
| 项目标题 |
The anti-tumor effects of Low-dose Radiotherapy Combined with Dual PD-L1 and VEGFA Blockade in DEN+CCI4 HCC mice model |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Atezolizumab (anti-PD-L1) combined with bevacizumab (anti-VEGFA) (T+A) is the first-line immunotherapy for advanced hepatocellular carcinoma (HCC), but the number of patients who benefit from this regimen remains limited. Here, we combined dual PD-L1 and VEGFA blockade (DPVB) with low-dose radiotherapy (LDRT), which instantly inflames tumors, rendering them vulnerable to immunotherapy. The combinatorial therapy exhibited superior antitumor efficacy mediated by CD8+ T cells in various preclinical HCC models. This is about the effect of LDRT combined with DPVB in the DEN+CCI4 mice model. |
| 样品范围 |
Single cell |
| 发布日期 |
2023-10-23 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38001101
|
Low-dose radiotherapy combined with dual PD-L1 and VEGFA blockade elicits antitumor response in hepatocellular carcinoma mediated by activated intratumoral CD8+ exhausted-like T cells
|
Nature Communications
|
10.1038/s41467-023-43462-1
|
2023
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82103448
|
|
|
|
| 提交者 |
Siqi
Li (celiasiqi@163.com)
|
| 提交单位 |
Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China |
| 提交日期 |
2023-09-12 |
