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Accession PRJCA019745
Title Investigating Cellular Similarities and Differences Between Upper Tract Urothelial Carcinoma and Bladder Urothelial Carcinoma using Single-Cell Sequencing
Relevance Medical
Data types Transcriptome or Gene expression
Organisms Homo sapiens
Description Upper tract urothelial carcinoma (UTUC) and bladder urothelial carcinoma (BLCA) both originate from uroepithelial tissue, sharing remarkably similar clinical manifestations and therapeutic modalities. However, emerging evidence suggests that identical treatment regimens may lead to less favorable outcomes in UTUC. This necessitates an investigation into the molecular underpinnings of UTUC and its biological differences compared to BLCA. In the present study, we conducted a comprehensive analysis using single-cell RNA sequencing (scRNA-seq) on three UTUC cases and four normal ureteral tissues, a total of 66,881 high-quality single-cell were captured. We combined this data with publicly available datasets from previous BLCA studies and RNA sequencing (RNA-seq) data for both cancer types. This collective analysis allowed us to delineate the transcriptional differences among distinct cell subsets within the microenvironment, thus identifying critical factors contributing to UTUC progression and phenotypic differences from BLCA.
Sample scope Single cell
Release date 2024-07-01
Publication
PubMed ID Article title Journal name DOI Year
38903524 Investigating cellular similarities and differences between upper tract urothelial carcinoma and bladder urothelial carcinoma using single-cell sequencing Frontiers in Immunology 10.3389/fimmu.2024.1298087 2024
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 81260108
National Natural Science Foundation of China (NSFC) 2021GXNSFAA196071
Submitter Zengnan Mo (mozengnan@gxmu.edu.cn)
Organization Guangxi Medical University
Submission date 2023-09-11

Project Data

Resource name Description