| 项目编号 |
PRJCA019779 |
| 项目标题 |
Function and mechanism study of CD146 which is the receptor of ANGPTL2 in obesity |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Obesity and its complications are increasingly becoming a major threat to human health. At present, the research on obesity mainly focuses on intracellular transcription factors and extracellular cytokines, and there is still a lack of membrane receptor molecules which can be targeted to treat obesity. For example, ANGPTL2 is one of the important adipocytokines, which promotes obesity and its complications. However, the mechanism that ANGPTL2 promotes obesity is not clear. Recently, when we study the function of CD146 which is high expressed in adipocyte, we find that ANGPTL2 interacts with CD146 directly in adipocytes, and anti-CD146 antibody blocked CD146-ANGPTL2 interaction. Systemic or adipose tissue-specific knockout of CD146 protects mice from obesity and related detrimental effects. Thus, we propose that CD146 is the key receptor for transmitting ANGPTL2 signaling from extracellular to intracellular in the development of obesity and related diseases. In this study, we will take advantage of various CD146 knockout mouse models and clinical samples to study the function and molecular mechanism of ANGPTL2-CD146 in promoting obesity systematically and the therapy effects of targeting CD146 in obesity. This study will provide a new molecular mechanism for obesity and provide a new target for obesity treatment. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-10-04 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 37944525
|
CLMP is a tumor suppressor that determines all-trans retinoic acid response in colorectal cancer
|
Developmental Cell
|
10.1016/j.devcel.2023.10.006
|
2023
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
8200035861
|
|
|
|
| 提交者 |
Peggy
Hao (peggyhao@outlook.com)
|
| 提交单位 |
Beijing Children's Hospital |
| 提交日期 |
2023-09-13 |
