| Accession |
PRJCA019891 |
| Title |
scRNA-seq of MC38 tumors after recombinant oncolytic adenovirus treatment |
| Relevance |
Medical |
| Data types |
Single cell sequencing
|
| Organisms |
Mus musculus
|
| Description |
To better understand the mechanism associated with precise tumor regression achieved with the different OAd treatments, we performed comprehensive and unbiased scRNA-seq of MC38 tumors to examine the cellular transcriptomic changes in the TME. Two days after the third injection, tumors were collected, and scRNA-seq analysis was performed on MC38 tumors treated with PBS, OAd-null, OAd-SIRPα-Fc, OAd-Siglec10-Fc or OAd-TIGIT-Fc. Following gene expression normalization for read depth and mitochondrial read count, we obtained high-quality expression data for 33758 cells from MC38 tumors. |
| Sample scope |
Single cell |
| Release date |
2023-11-01 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Major Scientific and Technological Special Project for "Significant New Drugs Development"
|
|
2018ZX09201018-013
|
|
| Natural Science Foundation Project of Sichuan
|
|
2022NSFSC0848
|
|
|
|
| Submitter |
Daoyuan
Xie (xiedaoyuan@alu.scu.edu.cn)
|
| Organization |
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy |
| Submission date |
2023-09-18 |
