Accession

PRJCA019907

Title

CNS Immune Ecosystem Rearchitecture Enforce Therapeutic Attrition of TKI treatment in Brain Metastatic Lung Cancer

Relevance

Medical

Data types

Single cell sequencing

Organisms

Mus musculus
Homo sapiens

Description

Lung cancer brain metastasis (LCBM), the most common intracranial tumor presents a significant clinical obstacle. We applied single-cell RNA sequencing of LCBM from 12 patients, expecting to explore the tumor characteristics and the heterogeneity of tumor environment.

Sample scope

Single cell

Release date

2024-10-04

Grants

Agency	program	Grant ID
Shanghai Hospital Development Center	Clinical Research Plan of Shanghai Hospital Development Center	SHDC2020CR5004
National Natural Science Foundation of China (NSFC)	General Program	82072784
National Natural Science Foundation of China (NSFC)	General Program	82072785
Ministry of Science and Technology of the People's Republic of China (MOST)	National Key Technologies R&D Program	2022YFA1106400
Ministry of Science and Technology of the People's Republic of China (MOST)	National Key Technologies R&D Program	2022YFC2406703
Ministry of Science and Technology of the People's Republic of China (MOST)	National Key Technologies R&D Program	2022YFC3401600

Submitter

Wei Hua (hs_huawei@126.com)

Organization

Huashan Hospital Fudan University

Submission date

2023-09-18

Project Data

Resource name	Description
BioSample (4)	-
SAMC3089376	W7
SAMC3089375	W6
SAMC3089374	W5
SAMC3089373	W4
GSA (1)	-
CRA012852	Single-Cell Transcriptome Profiling of CD45+ Cells in a Murine Lung Cancer Brain Metastasis Model