| 项目编号 |
PRJCA020241 |
| 项目标题 |
Mettl1 knockout regulates RNA translation |
| 涉及领域 |
Medical |
| 数据类型 |
Epigenomics
Transcriptome or Gene expression
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
To identify differentially translated mRNAs upon Mettl1 deletion, we isolated limb mesenchymal cells at E14.5 and subject them to ribosome profiling, in which the ribosome-protected mRNA fragments were collected for sequencing. Gene ontology and pathway analyses showed that TE-down mRNAs were enriched for actin cytoskeleton and muscle contraction. TE-up mRNAs were enriched for metabolic processes and signaling in fatty acids synthesis, TCA cycle, branched-chain amino acid (BCAA) degradation and one carbon metabolism upon Mettl1 deletion |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-11-13 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39255038
|
Metabolic rewiring during bone development underlies tRNA m7G-associated primordial dwarfism
|
The Journal of Clinical Investigation
|
10.1172/JCI177220
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82125006
|
|
|
|
| 提交者 |
Quan
Yuan (yuanquan@scu.edu.cn)
|
| 提交单位 |
West China Hospital of Stomatology, Sichuan University |
| 提交日期 |
2023-10-01 |
