| Accession |
PRJCA020241 |
| Title |
Mettl1 knockout regulates RNA translation |
| Relevance |
Medical |
| Data types |
Epigenomics
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
|
| Description |
To identify differentially translated mRNAs upon Mettl1 deletion, we isolated limb mesenchymal cells at E14.5 and subject them to ribosome profiling, in which the ribosome-protected mRNA fragments were collected for sequencing. Gene ontology and pathway analyses showed that TE-down mRNAs were enriched for actin cytoskeleton and muscle contraction. TE-up mRNAs were enriched for metabolic processes and signaling in fatty acids synthesis, TCA cycle, branched-chain amino acid (BCAA) degradation and one carbon metabolism upon Mettl1 deletion |
| Sample scope |
Multiisolate |
| Release date |
2024-11-13 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 39255038
|
Metabolic rewiring during bone development underlies tRNA m7G-associated primordial dwarfism
|
The Journal Of Clinical Investigation
|
10.1172/JCI177220
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82125006
|
|
|
|
| Submitter |
Quan
Yuan (yuanquan@scu.edu.cn)
|
| Organization |
West China Hospital of Stomatology, Sichuan University |
| Submission date |
2023-10-01 |
