| 项目编号 |
PRJCA020509 |
| 项目标题 |
Dissecting genetic information, transcriptome regulation and TME of MTCs and CTCs by scRNA-seq in breast cancer brain metastasis |
| 涉及领域 |
Medical |
| 数据类型 |
Whole genome sequencing
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Brain is the most common site of breast cancer metastasis, which is an increasing clinical problem and also is the leading reason for death in patients with metastatic breast cancer. Regrettably, our understanding of the biology of breast cancer brain metastasis (BCBM). is remains rudimentary. In this study, we performed a comprehensive multi-omics analysis including scRNA-seq in 23 patients and DNA-seq in 47 patients with BCBM. We interrogated the trajectory of BC cells from "primary - peripheral blood - circulating tumor cells (CTCs) -BM - cerebrospinal fluid (CSF)". We explored the genetic features, the regulation of transcriptomics, and the tumor immune microenvironment (TIME) of BCBM. |
| 样品范围 |
Single cell |
| 发布日期 |
2023-10-26 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82330083
|
|
|
|
| 提交者 |
Tao
Wang (wangtao733073@163.com)
|
| 提交单位 |
The Fifth Medical Center of Chinese PLA General Hospital |
| 提交日期 |
2023-10-15 |
