| Accession |
PRJCA020676 |
| Title |
Exploring molecular profiles of osteogenically differentiated aortic valvular interstitial cells |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
Aortic valve calcifications are often associated with calcium deposition and tissue mineralization, resulting in stiffness and dysfunction. To better understand the diversity of molecular and cellular processes for calcification in valve structures, we isolated human aortic valve interstitial cells (AVICs) and exposed them to calcification stimulation. RNA-seq revealed that in response to calcified stimuli, AVIC activates a robust ossification program, although the signaling pathways, cellular processes, and osteogenesis-related markers involved are diverse. In conclusion, this study provides a wealth of information suggesting that the pathogenesis of aortic valve calcification may be much more than previously understood. |
| Sample scope |
Monoisolate |
| Release date |
2023-12-06 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82271606
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32000971
|
|
|
|
| Submitter |
Jinyong
Chen (chen_jinyong@zju.edu.cn)
|
| Organization |
The Second Affiliated Hospital, Zhejiang University School of Medicine |
| Submission date |
2023-10-21 |
