| Accession |
PRJCA020678 |
| Title |
Cellular landscapes of osteogenically differentiated valvular interstitial cells stimulated with XCT790-loaded nanoparticles |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
The pathogenesis of calcific aortic valve disease (CAVD) is unknown. XCT790 is a specific inhibitor of estrogen-related receptor α (ERR-α) that inhibits valve calcification in mouse model. Here, we designed a nanocarrier targeting osteoblastic differentiated valve interstitial cells (VICs) for targeted delivery of XCT790 to the calcified site. We stimulated osteogenically differentiated VICs with this targeted nanoparticle, and performed RNA-seq to evaluate the transcriptional alterations of VICs and explore specific mechanisms. |
| Sample scope |
Monoisolate |
| Release date |
2023-12-06 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82271606
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32000971
|
|
|
|
| Submitter |
Jinyong
Chen (chen_jinyong@zju.edu.cn)
|
| Organization |
The Second Affiliated Hospital, Zhejiang University School of Medicine |
| Submission date |
2023-10-21 |
