1. Home
  2. Browse
  3. PRJCA020686
项目编号 PRJCA020686
项目标题 Generation of three-dimensional meat-like tissue from stable pig epiblast stem cells
涉及领域 Agricultural
数据类型 Metabolome
物种名称 Sus scrofa
描述信息 Cultured meat (CM) production has emerged as a breakthrough technology for the global food industry, with the potential to reduce challenges associated with environmental sustainability, global public health, animal welfare, and competition for food between humans and animals. The muscle stem cell lines currently used for CM production cannot be passaged in vitro for extended periods of time. Here, we successfully developed a directional differentiation system of porcine pregastrulation epiblast stem cells (pgEpiSCs) with stable cellular features and achieved serum-free myogenic differentiation of the pgEpiSCs. The pgEpiSCs-derived skeletal muscle progenitor cells and skeletal muscle fibers show typical muscle cell characteristics and display skeletal muscle transcriptional features during myogenic differentiation. Importantly, we further established a three-dimensional differentiation system for shaping cultured tissue by screening plant-based edible scaffolds of non-animal origin, followed by the generation of pgEpiSCs-derived CM. These advances provide a novel technical approach for the development of CM.
样品范围 Monoisolate
发布日期 2023-10-22
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
38071210 Generation of three-dimensional meat-like tissue from stable pig epiblast stem cells Nature Communications 10.1038/s41467-023-44001-8 2023
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
Ministry of Science and Technology of the People's Republic of China (MOST) National Key Technologies R&D Program 2022YFD1302201
National Natural Science Foundation of China (NSFC) General Program 31970825
National Natural Science Foundation of China (NSFC) General Program 31772601
National Natural Science Foundation of China (NSFC) General Program 31972099
National Natural Science Foundation of China (NSFC) General Program 32172143
Future Functional FoodR&D Program of China Agricultural University SJ2021002004
China NationaPostdoctoral Program for InnovativeTalents BX20220344
Beijing Natural Science Foundation 6192005
Plan 111 B12008
Ministry of Science and Technology of the People's Republic of China (MOST) National Key Technologies R&D Program 2016YFA0100202
提交者 Dengfeng Gao (gaodf@cau.edu.cn)
提交单位 China Agricultural University
提交日期 2023-10-22

项目包含数据信息

资源名称 描述