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项目编号 PRJCA020754
项目标题 Gut microbiome in Crohn's disease
涉及领域 Medical
数据类型 Whole genome sequencing
Metagenome
Transcriptome or Gene expression
物种名称 Mus musculus
Achromobacter pulmonis
human gut metagenome
描述信息 Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract that is currently increasing in prevalence worldwide. Mesenteric adipose tissue (mAT) hyperplasia, known as creeping fat, is a pathologic characteristic of CD. Bacteria within the fatty tissue, mAT-resident bacteria, play a role in the pathogenesis of CD. In our previously reported cohort, Achromobacter pulmonis was the most abundant and prevalent bacteria cultivated from creeping fat. Here, we obtained the complete genome sequence of the strain by Shotgun and Nanopore sequencing and revealed the immune response of macrophages infected with Achromobacter pulmonis species by RNAseq. Besides, we applied fecal shotgun metagenomic sequencing in a cohort of Chinese CD patients and healthy controls to investigate the alteration of microbiota and virulence factors in this disease.
样品范围 Multispecies
发布日期 2024-08-01
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
39216231 Gut bacterial type III secretion systems aggravate colitis in mice and serve as biomarkers of Crohn's disease Ebiomedicine 10.1016/j.ebiom.2024.105296 2024
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) the National Natural Science Foundation of China 32000096 Roles of Achromobacter Type III Secretion System in Crohn
提交者 Jun Xu (xujun27@mail2.sysu.edu.cn)
提交单位 Sun Yat-sen University
提交日期 2023-10-24

项目包含数据信息

资源名称 描述
BioSample (70)  show -
GSA (3) -
CRA013239 Gut microbiome in Crohn's disease
CRA013192 Transcription profile of macrophages
CRA013193 Achromobacter pulmonis mAT1 complete genome