| 项目编号 |
PRJCA020782 |
| 项目标题 |
Impaired CD103+ T cell accumulation facilitates oxidative damage induced lung adenocarcinoma |
| 涉及领域 |
Medical |
| 数据类型 |
Exome
Genome sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Immune microenvironment plays essential roles in tumor progression. The molecular mechanism underlying the regulation of immune surveillance in tumor initiation remains to be elucidated. Here we show that mice with T cell-specific deletion of the mediator subunit Med23 develops the alveolar epithelial type II cells (AT2 cells) originated lung adenocarcinoma, and such lung tumors displays an increased mutation frequency of oncogenes. Notably, the tumorigenesis of lung adenocarcinoma in Med23-deficient mice is promoted by the accumulation of AT2 cells under oxidative stress and oxidative DNA damage. Antioxidant treatment partially rescues spontaneous lung adenocarcinoma in Med23-deficient mice. Moreover, we find that loss of MED23 impairs the accumulation of lung CD103+ T cells, usually recognized as tissue resident T cells. CD103+ T cells have the ability to scavenge AT2 cells bearing oxidative DNA damage and prevent the tumorigenesis of lung adenocarcinoma. Mechanistically, CD103+ T cells predispose cells with high-level of oxidative stress to apoptosis. Collectively, our study finds MED23 is the key regulator of CD103+ T cell in lungs and reveals the immunosurveillance of CD103+ T cells in tumorigenesis. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2023-10-25 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
31970835
|
NKT cell subpopulation analysis and functional study
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2022YFA1103902
|
Study on the signaling regulatory network of stem cell tumorigenesis
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2020YFA0509102
|
Novel protein machinery in intestinal immune cell migration, localization, activation and differentiation
|
|
|
| 提交者 |
Jiahao
Wang (wangjiahao2019@sibcb.ac.cn)
|
| 提交单位 |
SIBCB, CAS |
| 提交日期 |
2023-10-13 |
