| 项目编号 |
PRJCA021197 |
| 项目标题 |
FTO modulates the innate immune and inflammatory response to human respiratory syncytial virus |
| 涉及领域 |
Medical |
| 数据类型 |
Genome sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Using human bronchial epithelial cells (BEAS-2B) infected by RSV as a model, we demonstrated that m6A demethylase FTO increased and the level of m6A decreased in infected cells. Meanwhile, in throat swab samples from RSV infected people, similar results were obtained. We also found that the proliferative ability of BEAS-2B cells was significantly inhibited during infection. However, reducing FTO not only slowed down the decline of BEAS-2B cell proliferation, but also inhibited the replication of RSV as well as the signaling pathway of TLR7/MyD88, which led to a reduction of pro-inflammatory cytokines IL-1/6/8. In addition, reducing FTO triggered higher levels of IFN-I during infection. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-11-30 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39474078
|
The GDF6-FTO axis modulates the innate immune and inflammatory response to human respiratory syncytial virus
|
iScience
|
10.1016/j.isci.2024.111038
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Science and Technology Project of Guizhou Province
|
General Program
|
ZK-2022-581
|
Study on the molecular mechanism of FTO regulating immune response during RSV infection
|
|
|
| 提交者 |
Zhu
Li (lizhu330@163.com)
|
| 提交单位 |
The Third Affiliated Hospital of Zunyi Medical University |
| 提交日期 |
2023-11-10 |
