项目编号

PRJCA021379

项目标题

Single-cell RNA and TCR/BCR sequencing reveals distinct molecular pathway in immune checkpoint inhibitor-related pneumonitis in non-small cell lung cancer

涉及领域

Medical

数据类型

Single cell sequencing

物种名称

Homo sapiens

描述信息

In this project, the experimental group was the immune checkpoint inhibitor-related pneumonitis(CIP) tissue samples of advanced non-small cell lung cancer patients after receiving immunotherapy treatment. We comprehensively analyzed the immune landscape during CIP onset using scRNA/TCR/BCR-seq, it could serve as a novel therapeutic strategy for CIP treatment and provide biomarkers and intervention targets for precision medicine.

样品范围

Single cell

发布日期

2024-01-31

出版信息

PubMed ID	文章标题	杂志名称	Doi	发表年份
41298513	Uncovering the immune mechanisms underlying the emergence of immunotherapy-induced pneumonitis in lung cancer patients	Nature Communications	10.1038/s41467-025-66509-x	2025

项目资金来源

机构	项目类型	授权项目ID	授权项目名称
Guangzhou Municipal Health Commission	Guangzhou Science and Technology Major Clinical Project	2023C-DZ06
Beijing Xisike Clinical Oncology Research Foundation	Xisike pierrefabre Cancer Research Grant Program	Ypierrefabre2021010023

提交者

Xinqing Lin (linxinqing81@163.com)

提交单位

The First Affiliated Hospital of Guangzhou Medical University

提交日期

2023-11-17

项目包含数据信息

资源名称	描述
BioSample (16) show	-
SAMC4645844	Single cell sequencing/TCR/BCR of human immunotherapy-induced pneumonitis sample P9
SAMC4645843	Single cell sequencing of human immunotherapy-induced pneumonitis sample P8
SAMC4645842	Single cell sequencing of human immunotherapy-induced pneumonitis sample P7
SAMC4645841	Single cell sequencing/TCR/BCR of human immunotherapy-induced pneumonitis sample P6
SAMC4645840	Single cell sequencing/TCR/BCR of human Lung cancer adjacent tissue sample N7
SAMC4645839	Single cell sequencing/TCR/BCR of human Lung cancer adjacent tissue sample N6
SAMC3362604	Single cell sequencing/TCR/BCR of human Lung cancer adjacent tissue sample N5
SAMC3362603	Single cell sequencing/TCR/BCR of human Lung cancer adjacent tissue sample N4
SAMC3362602	Single cell sequencing/TCR/BCR of human Lung cancer adjacent tissue sample N3
SAMC3362601	Single cell sequencing/TCR/BCR of human immunotherapy-induced pneumonitis sample P5
SAMC3362600	Single cell sequencing/TCR/BCR of human immunotherapy-induced pneumonitis sample P4
SAMC3362599	Single cell sequencing/TCR/BCR of human immunotherapy-induced pneumonitis sample P3
SAMC3362598	Single cell sequencing/TCR/BCR of human immunotherapy-induced pneumonitis sample P2
SAMC3362597	Single cell sequencing/TCR/BCR of human Lung cancer adjacent tissue sample N2
SAMC3362596	Single cell sequencing/TCR/BCR of human Lung cancer adjacent tissue sample N1
SAMC3362595	Single cell sequencing/TCR/BCR of human immunotherapy-induced pneumonitis sample P1