| Accession |
PRJCA021454 |
| Title |
Integrated Metabonomics, 16S rDNA and mRNA sequencing to investigate the regulation of Shaoyao Decoction on DSS-induced ulcerative colitis in mice |
| Relevance |
Medical |
| Data types |
Targeted metabolomics for SCFAs in serum
|
| Organisms |
Mus
|
| Description |
Traditional Chinese medicine (TCM), had shown significantly curative effect in treating ulcerative colitis (UC) in the clinic with unclear mechanism. Therefore, we performed this study to explore the pharmacological mechanism by using 16S rDNA, mRNA sequencing and targeted metabolomics. We found that SYD may be involved in modulating the local inflammatory response in the intestine via the intestinal flora and its metabolites, as evidenced by the alpha indices, the beta distances, and the specific genera of intestinal bacteria relative abundance, as well as Short-chain fatty acids (SCFAs) alterations in serum and faecal. |
| Sample scope |
Multiisolate |
| Release date |
2024-01-01 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
82004249
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Basic Research Program of China (973 Program)
|
2019YFC1710104
|
|
| China Postdoctoral Foundation
|
China Postdoctoral Foundation
|
2019M660571
|
|
|
|
| Submitter |
yini
YINI
li (lyn@bucm.edu.cn)
|
| Organization |
Beijing University of Chinese Medicine |
| Submission date |
2023-11-21 |
