| 项目编号 | PRJCA021714 | ||||||||||||
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| 项目标题 | A Prospective Study of Circulating Tumor DNA Serial Monitoring of Tislelizumab immunotherapy Responses and Relapse as second-line monotherapy in metastatic Esophageal Carcinoma | ||||||||||||
| 涉及领域 | Medical | ||||||||||||
| 数据类型 |
Variation
Genome sequencing and assembly |
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| 物种名称 | Homo sapiens | ||||||||||||
| 描述信息 | We prospectively enrolled and collected endoscopic biopsy samples from 12 patients with advanced ESCC treated with tislelizumab. Plasma was collected before and after every 2-3 treatment cycle of tislelizumab and when disease progression. Targeted sequencing of 425 genes on plasma cell-free DNA, DNA from leukocytes, and fixed esophageal tumor biopsies were performed. The patients underwent imaging analyses every 6-8 weeks until disease progression. The association between status and changes in circulating tumor DNA (ctDNA) following tislelizumab immunotherapy and response, tumor progression, and survival was determined. | ||||||||||||
| 样品范围 | Monoisolate | ||||||||||||
| 发布日期 | 2023-12-15 | ||||||||||||
| 项目资金来源 |
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| 提交者 | XINMIN YU (yuxm@zjcc.org.cn) | ||||||||||||
| 提交单位 | zhejiang cancer hosipital | ||||||||||||
| 提交日期 | 2023-12-01 |
| 资源名称 | 描述 |
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| BioSample (59) show | - |