| 项目编号 |
PRJCA021815 |
| 项目标题 |
OA cartilage eQTL |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Cartilage is an important component of the joint and plays a critical role in the pathogenesis of osteoarthritis (OA). The study of gene expression regulation mechanism in cartilage is of great importance to elucidate the genetic mechanism of OA. However, the regulatory landscape of gene expression in cartilage remains poorly understood, due to the absence of large-scale resources. Here, we aimed to fill this knowledge gap by integrating genomics with transcriptomics features of human knee cartilage from up to 204 OA patients. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-05-02 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40577937
|
Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritis
|
EBioMedicine
|
10.1016/j.ebiom.2025.105821
|
2025
|
| 41820402
|
Genetic alternative splicing regulation mapping of cartilage and synovium reveals tissue-specific mechanisms of joint-related traits
|
Nature Communications
|
10.1038/s41467-026-70419-x
|
2026
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
32170616
|
|
|
|
| 提交者 |
Tie-Lin
Yang (yangtielin@xjtu.edu.cn)
|
| 提交单位 |
Xi'an Jiaotong University |
| 提交日期 |
2023-12-04 |
