| 项目编号 |
PRJCA021923 |
| 项目标题 |
The changes of local microenvironment and the key targets of adenoma canceration during the natural occurrence of colorectal adenocarcinoma were investigated by single cell sequencing technology |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
In this study, tissue samples from a rare patient with both intestinal adenoma and adenocarcinoma were analyzed using a combination of single-cell sequencing and spatial transcriptome sequencing. In the tested cells, we identified different tumor-associated fibroblast cell phenotypes, T cell phenotypes and immune components. This study demonstrates the tumor immune microenvironment during the progression of intestinal adenomas to adenocarcinoma. The study provided valuable insights for potential therapeutic interventions targeting the tumor microenvironment. |
| 样品范围 |
Single cell |
| 发布日期 |
2024-03-26 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38455977
|
Circulation immune cell landscape in canonical pathogenesis of colorectal adenocarcinoma by CyTOF analysis
|
iScience
|
10.1016/j.isci.2024.109229
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| The Second Affiliated Hospital of Zhejiang University School of Medicine
|
|
N/A
|
|
| The National Key R&D Program of China
|
|
2017YFC0908200
|
|
|
|
| 提交者 |
Jiasheng
Xu (1821286450@qq.com)
|
| 提交单位 |
The Second Affiliated Hospital, Zhejiang University School of Medicine |
| 提交日期 |
2023-12-10 |
