| Accession |
PRJCA021923 |
| Title |
The changes of local microenvironment and the key targets of adenoma canceration during the natural occurrence of colorectal adenocarcinoma were investigated by single cell sequencing technology |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
In this study, tissue samples from a rare patient with both intestinal adenoma and adenocarcinoma were analyzed using a combination of single-cell sequencing and spatial transcriptome sequencing. In the tested cells, we identified different tumor-associated fibroblast cell phenotypes, T cell phenotypes and immune components. This study demonstrates the tumor immune microenvironment during the progression of intestinal adenomas to adenocarcinoma. The study provided valuable insights for potential therapeutic interventions targeting the tumor microenvironment. |
| Sample scope |
Single cell |
| Release date |
2024-03-26 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38455977
|
Circulation immune cell landscape in canonical pathogenesis of colorectal adenocarcinoma by CyTOF analysis
|
iScience
|
10.1016/j.isci.2024.109229
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| The Second Affiliated Hospital of Zhejiang University School of Medicine
|
|
N/A
|
|
| The National Key R&D Program of China
|
|
2017YFC0908200
|
|
|
|
| Submitter |
Jiasheng
Xu (1821286450@qq.com)
|
| Organization |
The Second Affiliated Hospital, Zhejiang University School of Medicine |
| Submission date |
2023-12-10 |
