项目编号

PRJCA022036

项目标题

PBMC Single-cell Transcriptomics of juvenile idiopathic arthritis

涉及领域

Medical

数据类型

Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing

物种名称

Homo sapiens

描述信息

The presence or absence of human leukocyte antigen (HLA-B27) suggests that juvenile idiopathic arthritis (JIA) is heterogeneous. Understanding the response mechanism of immune cells to different subtypes of JIA is the key to formulating therapeutic strategies for different subtypes of JIA. Our study provided evidence of cellular and molecular levels of involvement in JIA pathogenesis and identified the critical roles for T cells in JIA pathogenesis. Furthermore, our results suggested that there were significant differences in T cell composition and gene expression between HLA-B27+ JIA patients and HLA-B27- JIA patients, which may contribute to the phenotypic differences between HLA-B27-positive and HLA-B27-negative JIA subtypes. Our findings indicated that CCR7+/RELB+/IRF1+ triple positive T cells could damage the cartilage of HLA-B27+ JIA by producing cytokines such as IL-17. This mechanism enables CCR7+/RELB+/IRF1+ triple positive T cells to act as a therapeutic target for HLA-B27+ JIA patients.

样品范围

Single cell

发布日期

2023-12-13

出版信息

PubMed ID	文章标题	杂志名称	Doi	发表年份
40406113	Single cell RNA-sequencing identified CCR7+/RELB+/IRF1+ T cell responding for juvenile idiopathic arthritis pathogenesis	Frontiers in Immunology	10.3389/fimmu.2025.1528446	2025

项目资金来源

机构	项目类型	授权项目ID	授权项目名称
National Natural Science Foundation of China (NSFC)		82270249

提交者

Yifei Li (liyfwcsh@scu.edu.cn)

提交单位

West China Second University Hospital, Sichuan University

提交日期

2023-12-13

项目包含数据信息

资源名称	描述
BioSample (10) show	-
SAMC3277093	Peripheral blood mononuclear cells were obtained from healthy control subjects
SAMC3277092	Peripheral blood mononuclear cells were obtained from healthy control subjects
SAMC3277091	Peripheral blood mononuclear cells were obtained from healthy control subjects
SAMC3277090	Peripheral blood mononuclear cells were obtained from hla-b27 negative JIA patients
SAMC3277089	Peripheral blood mononuclear cells were obtained from hla-b27 negative JIA patients
SAMC3277088	Peripheral blood mononuclear cells were obtained from hla-b27 negative JIA patients
SAMC3277087	Peripheral blood mononuclear cells were obtained from hla-b27 positive JIA patients
SAMC3277086	Peripheral blood mononuclear cells were obtained from hla-b27 positive JIA patients
SAMC3277085	Peripheral blood mononuclear cells were obtained from hla-b27 positive JIA patients
SAMC3277084	Peripheral blood mononuclear cells were obtained from hla-b27 positive JIA patients