| Accession |
PRJCA022071 |
| Title |
Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis |
| Relevance |
Medical |
| Data types |
Whole genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Previously, we isolated CRC stem cells from patient samples and screened the gene expression in CRC stem cells. The results showed that DKK4 highly expressed in CRC stem cells and greatly decreased its expression in cancer cells derived from the differentiation of CRC stem cells. The distinctive DKK4 expressing patterns in CRC cells drive us to address roles of DKK4, an inhibitor of Wnt/beta-catenin signalling pathway, in CRC formation and progression. |
| Sample scope |
Multiisolate |
| Release date |
2023-12-14 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38519641
|
Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
|
Oncogene
|
10.1038/s41388-024-03008-1
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81972592
|
|
| the 1.3.5 project for disciplines of excellence of West China Hospital
|
|
ZYGD20007
|
|
|
|
| Submitter |
Xue
Li (lixue-87@163.com)
|
| Organization |
West China Hospital of Sichuan University |
| Submission date |
2023-12-14 |
