| Accession |
PRJCA022090 |
| Title |
Single cell analysis revealed immune heterogeneity and its association with disease activity in rheumatoid arthritis |
| Relevance |
Medical |
| Data types |
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic autoimmune disease characterized by cartilage, bone damage, synovial inflammation, hyperplasia production of autoantibodies and systemic features. To gain an overall profiling of RA immune environment and its association with clinical data, we performed single cell transcriptome and VDJ sequencing on the mononuclear cells from peripheral blood (PBMC) and synovial fluid (SF) for two patients with anti-citrullinated protein autoantibodies (ACPA) high and low respectively. |
| Sample scope |
Single cell |
| Release date |
2024-08-04 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 39009881
|
Integration of single-cell and bulk RNA sequencing revealed immune heterogeneity and its association with disease activity in rheumatoid arthritis patients
|
Immunologic Research
|
10.1007/s12026-024-09513-5
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
82103347
|
|
|
|
| Submitter |
Xiaofan
Mao (xiaofanmao@126.com)
|
| Organization |
The First People's Hospital of Foshan |
| Submission date |
2023-12-15 |
