| 项目编号 |
PRJCA022090 |
| 项目标题 |
Single cell analysis revealed immune heterogeneity and its association with disease activity in rheumatoid arthritis |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic autoimmune disease characterized by cartilage, bone damage, synovial inflammation, hyperplasia production of autoantibodies and systemic features. To gain an overall profiling of RA immune environment and its association with clinical data, we performed single cell transcriptome and VDJ sequencing on the mononuclear cells from peripheral blood (PBMC) and synovial fluid (SF) for two patients with anti-citrullinated protein autoantibodies (ACPA) high and low respectively. |
| 样品范围 |
Single cell |
| 发布日期 |
2024-08-04 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39009881
|
Integration of single-cell and bulk RNA sequencing revealed immune heterogeneity and its association with disease activity in rheumatoid arthritis patients
|
Immunologic Research
|
10.1007/s12026-024-09513-5
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
82103347
|
|
|
|
| 提交者 |
Xiaofan
Mao (xiaofanmao@126.com)
|
| 提交单位 |
The First People's Hospital of Foshan |
| 提交日期 |
2023-12-15 |
