| 项目编号 |
PRJCA022206 |
| 项目标题 |
Urine metabolomics phenotyping in mild cognitive impairment and Alzheimer's disease |
| 涉及领域 |
Medical |
| 数据类型 |
metabolomics
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Alzheimer's disease is a prevalent disease with a heavy global burden and is suggested to be a metabolic disease in the brain in recent years. The metabolome is considered to be the most promising phenotype which reflects changes in genetic, transcript, and protein profiles as well as environmental effects. Aiming to obtain a comprehensive understanding and convenient diagnosis of MCI and AD from another perspective, researchers are working on AD metabolomics. Urine is more convenient which could reflect the change of disease at an earlier stage. Thus, we conducted a cross-sectional study to investigate urine metabolomics during AD continuum. We enrolled participants from China-Japan Friendship Hospital from April 2022 to November 2022, collected urine samples and conducted an LC-MS/MS analysis. Fifty-seven AD patients, 43 MCI patients and 62 CN subjects were enrolled. A total of 2140 metabolites were identified. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-12-19 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Urine metabolomics phenotyping and urinary biomarker exploratory in mild cognitive impairment and Alzheimer's disease
|
Frontiers in aging neuroscience
|
10.3389/fnagi.2023.1273807
|
|
| 38187356
|
Urine metabolomics phenotyping and urinary biomarker exploratory in mild cognitive impairment and Alzheimer’s disease
|
Frontiers in Aging Neuroscience
|
10.3389/fnagi.2023.1273807
|
2023
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
81974220
|
|
|
|
| 提交者 |
Yuye
Wang (pumcwyy@126.com)
|
| 提交单位 |
China-Japan Friendship Hospital |
| 提交日期 |
2023-12-19 |
