| Accession |
PRJCA022206 |
| Title |
Urine metabolomics phenotyping in mild cognitive impairment and Alzheimer's disease |
| Relevance |
Medical |
| Data types |
metabolomics
|
| Organisms |
Homo sapiens
|
| Description |
Alzheimer's disease is a prevalent disease with a heavy global burden and is suggested to be a metabolic disease in the brain in recent years. The metabolome is considered to be the most promising phenotype which reflects changes in genetic, transcript, and protein profiles as well as environmental effects. Aiming to obtain a comprehensive understanding and convenient diagnosis of MCI and AD from another perspective, researchers are working on AD metabolomics. Urine is more convenient which could reflect the change of disease at an earlier stage. Thus, we conducted a cross-sectional study to investigate urine metabolomics during AD continuum. We enrolled participants from China-Japan Friendship Hospital from April 2022 to November 2022, collected urine samples and conducted an LC-MS/MS analysis. Fifty-seven AD patients, 43 MCI patients and 62 CN subjects were enrolled. A total of 2140 metabolites were identified. |
| Sample scope |
Multiisolate |
| Release date |
2023-12-19 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Urine metabolomics phenotyping and urinary biomarker exploratory in mild cognitive impairment and Alzheimer's disease
|
Frontiers in aging neuroscience
|
10.3389/fnagi.2023.1273807
|
|
| 38187356
|
Urine metabolomics phenotyping and urinary biomarker exploratory in mild cognitive impairment and Alzheimer’s disease
|
Frontiers in Aging Neuroscience
|
10.3389/fnagi.2023.1273807
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81974220
|
|
|
|
| Submitter |
Yuye
Wang (pumcwyy@126.com)
|
| Organization |
China-Japan Friendship Hospital |
| Submission date |
2023-12-19 |
