| 项目编号 |
PRJCA022311 |
| 项目标题 |
Single cell Transcriptome Profiling of Infrapatellar Fat Pad |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Osteoarthritis (OA) is a prevalent joint disease affecting approximately 300 million individuals worldwide, and its pathogenesis remains incompletely elucidated. In recent years, the understanding of OA has evolved from being solely focused on cartilage to encompassing the entire joint. The infrapatellar fat pad (IFP), an adipose tissue component within the knee joint, has emerged as a potential contributor to the progression of knee osteoarthritis (KOA). To gain insights into the molecular mechanisms underlying OA occurrence and development, we conducted single-cell sequencing analysis on IFP samples obtained from five normal knee joints and five OA patients. Additionally, subcutaneous fat samples were collected from one OA patient and one healthy donor |
| 样品范围 |
Single cell |
| 发布日期 |
2024-03-08 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38522139
|
Single cell transcriptome profiling of infrapatellar fat pad highlights the role of interstitial inflammatory fibroblasts in osteoarthritis
|
International Immunopharmacology
|
10.1016/j.intimp.2024.111888
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
81974350
|
|
|
|
| 提交者 |
Hongxu
Pu (Hongxu_Pu@hust.edu.cn)
|
| 提交单位 |
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| 提交日期 |
2023-12-22 |
