| Accession |
PRJCA022311 |
| Title |
Single cell Transcriptome Profiling of Infrapatellar Fat Pad |
| Relevance |
Medical |
| Data types |
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Osteoarthritis (OA) is a prevalent joint disease affecting approximately 300 million individuals worldwide, and its pathogenesis remains incompletely elucidated. In recent years, the understanding of OA has evolved from being solely focused on cartilage to encompassing the entire joint. The infrapatellar fat pad (IFP), an adipose tissue component within the knee joint, has emerged as a potential contributor to the progression of knee osteoarthritis (KOA). To gain insights into the molecular mechanisms underlying OA occurrence and development, we conducted single-cell sequencing analysis on IFP samples obtained from five normal knee joints and five OA patients. Additionally, subcutaneous fat samples were collected from one OA patient and one healthy donor |
| Sample scope |
Single cell |
| Release date |
2024-03-08 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38522139
|
Single cell transcriptome profiling of infrapatellar fat pad highlights the role of interstitial inflammatory fibroblasts in osteoarthritis
|
International Immunopharmacology
|
10.1016/j.intimp.2024.111888
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81974350
|
|
|
|
| Submitter |
Hongxu
Pu (Hongxu_Pu@hust.edu.cn)
|
| Organization |
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| Submission date |
2023-12-22 |
