Accession

PRJCA022432

Title

The importance of microbial driven Sesquiterpenoid and triterpenoid biosynthesis in end-stage renal disease patients receiving peritoneal dialysis

Relevance

Medical

Data types

Metagenome

Organisms

human gut metagenome

Description

Peritoneal dialysis is considered an important renal replacement therapy for the treatment of end-stage renal disease. The changes in the gut microbiota and the mechanisms involved after receiving this dialysis method are not fully understood. We performed birdshot macrogenomic sequencing of fecal samples from 18 patients with end-stage renal disease (ESRD), including 11 undialyzed patients and 7 peritoneal dialysis patients. We preliminarily analyzed the differences in gut microbiota between ESRD patients not undergoing dialysis and ESRD patients undergoing peritoneal dialysis. To further explore the potential mechanisms of peritoneal dialysis, we analyzed the gut microbiota, gut microbiota genes, and associated KEGG pathways. We found promotion of microbial-driven synthesis of triterpenes and triterpenoids in ESRD patients after peritoneal dialysis, which contributes to blood purification and improves circulation. Our study provides new insights into peritoneal dialysis treatment of ESRD patients.

Sample scope

Environment

Release date

2023-12-29

Grants

Agency	program	Grant ID	Grant title
National Natural Science Foundation of China (NSFC)		N/A

Submitter

Siqi Yao (ysqzj1999@163.com)

Organization

Central South University

Submission date

2023-12-27

Project Data

Resource name	Description
BioSample (18) show	-
SAMC3283319	Metagenome Shotgun Sequencing of human fecal L26
SAMC3283318	Metagenome Shotgun Sequencing of human fecal L25
SAMC3283317	Metagenome Shotgun Sequencing of human fecal L24
SAMC3283316	Metagenome Shotgun Sequencing of human fecal L23
SAMC3283315	Metagenome Shotgun Sequencing of human fecal L22
SAMC3283314	Metagenome Shotgun Sequencing of human fecal L21
SAMC3283313	Metagenome Shotgun Sequencing of human fecal L20
SAMC3283312	Metagenome Shotgun Sequencing of human fecal L19
SAMC3283311	Metagenome Shotgun Sequencing of human fecal L17
SAMC3283310	Metagenome Shotgun Sequencing of human fecal L9
SAMC3283309	Metagenome Shotgun Sequencing of human fecal L8
SAMC3283308	Metagenome Shotgun Sequencing of human fecal L7
SAMC3283307	Metagenome Shotgun Sequencing of human fecal L6
SAMC3283306	Metagenome Shotgun Sequencing of human fecal L5
SAMC3283305	Metagenome Shotgun Sequencing of human fecal L4
SAMC3283304	Metagenome Shotgun Sequencing of human fecal L3
SAMC3283303	Metagenome Shotgun Sequencing of human fecal L2
SAMC3283302	Metagenome Shotgun Sequencing of human fecal L1
GSA (1)	-
CRA014207	The importance of microbial driven Sesquiterpenoid and triterpenoid biosynthesis in end-stage renal disease patients receiving peritoneal dialysis