Accession

PRJCA022491

Title

obsessive-compulsive disorder 16S rRNA full-length sequencing

Relevance

Medical

Data types

Transcriptome or Gene expression

Organisms

Mus musculus

Description

To investigate the contribution of gut microbiota to the pathogenesis of OCD, we transplanted fecal microbiota from first-episode, drug-naive OCD patients or demographically matched healthy individuals into antibiotic-treated specific pathogen-free (SPF) mice and showed that colonization with OCD microbiota is sufficient to induce core behavioral deficits, including abnormal anxiety-like and compulsive-like behaviors. The fecal microbiota was analyzed using 16S rRNA full-length sequencing, and the results demonstrated a clear separation of the fecal microbiota of mice colonized with OCD and control microbiota.

Sample scope

Monoisolate

Release date

2024-01-01

Publication

PubMed ID	Article title	Journal name	DOI	Year
38273106	Human microbiota from drug-naive patients with obsessive-compulsive disorder drives behavioral symptoms and neuroinflammation via succinic acid in mice	Molecular Psychiatry	10.1038/s41380-024-02424-9	2024

Grants

Agency	program	Grant ID
National Natural Science Foundation of China (NSFC)	General Program	32271066
National Natural Science Foundation of China (NSFC)	General Program	82071518
National Natural Science Foundation of China (NSFC)	Key Program	82230045

Submitter

Dongdong Shi (laural.dong.shi@gmail.com)

Organization

Shanghai Jiao Topng University School of Medicine

Submission date

2023-12-29

Project Data

Resource name	Description
BioSample (38) show	-
SAMC3285953	RNA-seq of Mus musculus: the medial prefrontal cortex of brain
SAMC3285952	RNA-seq of Mus musculus: the medial prefrontal cortex of brain
SAMC3285951	RNA-seq of Mus musculus: the medial prefrontal cortex of brain
SAMC3285950	RNA-seq of Mus musculus: the medial prefrontal cortex of brain
SAMC3285949	RNA-seq of Mus musculus: the medial prefrontal cortex of brain
SAMC3285948	RNA-seq of Mus musculus: the medial prefrontal cortex of brain
SAMC3285947	RNA-seq of Mus musculus: the medial prefrontal cortex of brain
SAMC3285946	RNA-seq of Mus musculus: the medial prefrontal cortex of brain
SAMC3283379	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283378	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283377	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283376	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283375	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283374	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283373	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283372	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283371	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283370	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283369	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283368	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283367	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283366	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283365	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283364	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283363	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283362	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283361	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283360	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283359	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283358	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283357	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283356	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283355	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283354	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283353	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283352	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283351	16S rRNA full-length sequencing of Mus musculus fecal sample
SAMC3283350	16S rRNA full-length sequencing of Mus musculus fecal sample
GSA (2)	-
CRA014216	Transcriptome-wide alterations in medial prefrontal cortex in OCD-colonized mice
CRA014210	16S rRNA full-length sequencing of the fecal microbiota in mice colonized with OCD and control microbiota