| 项目编号 |
PRJCA022699 |
| 项目标题 |
Single-cell transcriptome profile of EV71-infected hiPSC-SOs. |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
The EV71 poses a serious threat to the health and lives of children. The EV71 can be transmitted by direct and indirect skin contact. Therefore, there is an urgent need to create novel skin models using human-derived cells to study the biology and pathogenesis of the virus and facilitate drug screening. In this study, human induced pluripotent stem cell-derived skin organoids (hiPSC-SOs) containing epithelial cells, hair follicles and nerve cells were established to study the effects of EV71 infection on the skin. Single-cell profile of EV71-infected skin organoids were first constructed to study the virulence, molecular characteristics and pathogenesis of EV71 infection. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-02-19 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40082449
|
A skin organoid-based infection platform identifies an inhibitor specific for HFMD
|
Nature Communications
|
10.1038/s41467-025-57610-2
|
2025
|
|
|
| 实验材料提供者 |
Ling Leng |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2021YFA1301603
|
|
|
|
| 提交者 |
Yunping
Zhu (zhuyunping@ncpsb.org.cn)
|
| 提交单位 |
National center for Protein science (Beijing) |
| 提交日期 |
2024-01-09 |
