| 项目编号 |
PRJCA022709 |
| 项目标题 |
Allelic transcriptomic profile reveals regulation of MZT in early human embryonic development |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Preimplantation embryo development is a complex and finely regulated process, especially for the transition from maternal to zygotic genome. The mechanism and key regulators of maternal-to-zygotic transition (MZT) in human embryo development remain largely unknown. By single-nucleotide polymorphism (SNP) allele genotype analysis of parental genome, we could determine the parent-of-origin of embryonic transcripts after single-cell RNA sequencing and further reveal key regulators during MZT. The present study may provide new insights into the complex regulation of MZT and specific functions of the parental genome in human early embryonic development. |
| 样品范围 |
Single cell |
| 发布日期 |
2024-11-26 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Allelic transcriptomic profiling identifies the role of PRD-like homeobox genes in human embryonic-cleavage-stage arrest
|
Developmental Cell
|
10.1016/j.devcel.2024.12.031
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
National Science Funds for Distinguished Young Scholars
|
82125013
|
|
|
|
| 提交者 |
Liying
Yan (yanliyingkind@aliyun.com)
|
| 提交单位 |
Peking University Third Hospital |
| 提交日期 |
2024-01-09 |
