| 项目编号 |
PRJCA022774 |
| 项目标题 |
Bilateral Breast Cancer Organoids |
| 涉及领域 |
Evolution |
| 数据类型 |
Exome
Raw sequence reads
Genome sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
We established organoid lines from two surgical tumor specimens of a BBC patient, with one line undergoing detailed pathological and genomic analysis. The derived BBC organoid mirrored the pathological features and breast cancer biomarkers of the original tumor (TNBC from the right breast). Whole Exome Sequencing (WES) revealed that the organoids' copy number variations (CNVs), single nucleotide polymorphisms (SNPs), and insertions/deletions (indels) were more closely aligned with their source tissue (TNBC) than other tumor tissues. Evolutionary analysis suggested that different tumor regions might evolve from a common ancestral layer. In this case, the development of BBC organoids indicated that simultaneous lesions with diverse molecular profiles shared a high degree of consistency in key tumor-driving mutations. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-01-11 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38800414
|
Patient-derived organoid elucidates the identical clonal origin of bilateral breast cancer with diverse molecular subtypes
|
Frontiers in Oncology
|
10.3389/fonc.2024.1361603
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| High-level Talent Innovation Support Program of Dalian
|
|
2021RD02
|
High-level Talent Innovation Support Program of Dalian Science and Technology Bureau
|
| Beijing Science & Technology Innovation Investment Management
|
|
KC2021-ZZ-0010-7
|
Beijing Science and Technology Innovation Medical Development Foundation
|
|
|
| 提交者 |
Shanshan
Liang (liangshanshan@dlu.edu.cn)
|
| 提交单位 |
Affiliated Zhongshan Hospital of Dalian University |
| 提交日期 |
2024-01-11 |
