| Accession |
PRJCA022810 |
| Title |
CAV2-expressing Nerves induce Metabolic Switch toward Mitochondrial Oxidative Phosphorylation to Promote Cancer Stemness |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
This study primarily discusses how tumors induce the expression of CAV2 in nerves, and how nerve-derived CAV2 facilitates the interaction between tumors and nerves. To investigate the impact of neural CAV2 on tumor cells, we conducted sequencing on head and neck squamous carcinoma cells co-cultured with wild-type trigeminal ganglia and those co-cultured with CAV2-knockout trigeminal ganglia. The results suggest that neural CAV2 plays a role in influencing the oxidative phosphorylation metabolic phenotype and the maintenance of stemness in tumor cells. |
| Sample scope |
Synthetic |
| Release date |
2024-01-12 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82073006
|
|
|
|
| Submitter |
Ze
Zhang (zhangze@tmu.edu.cn)
|
| Organization |
Tianjin cancer hospital |
| Submission date |
2024-01-12 |
