| 项目编号 |
PRJCA022810 |
| 项目标题 |
CAV2-expressing Nerves induce Metabolic Switch toward Mitochondrial Oxidative Phosphorylation to Promote Cancer Stemness |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This study primarily discusses how tumors induce the expression of CAV2 in nerves, and how nerve-derived CAV2 facilitates the interaction between tumors and nerves. To investigate the impact of neural CAV2 on tumor cells, we conducted sequencing on head and neck squamous carcinoma cells co-cultured with wild-type trigeminal ganglia and those co-cultured with CAV2-knockout trigeminal ganglia. The results suggest that neural CAV2 plays a role in influencing the oxidative phosphorylation metabolic phenotype and the maintenance of stemness in tumor cells. |
| 样品范围 |
Synthetic |
| 发布日期 |
2024-01-12 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82073006
|
|
|
|
| 提交者 |
Ze
Zhang (zhangze@tmu.edu.cn)
|
| 提交单位 |
Tianjin cancer hospital |
| 提交日期 |
2024-01-12 |
