| Accession |
PRJCA022926 |
| Title |
Photoaffinity probe-based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of Plasmodium falciparum |
| Relevance |
Model organism |
| Data types |
Phenotype or Genotype
|
| Organisms |
Plasmodium falciparum 3D7
|
| Description |
Malaria continues to pose a serious global health threat, and artemisinin remains the core drug for global malaria control. However, the situation of malaria resistance has become increasingly severe due to the emergence and spread of artemisinin resistance. In recent years, significant progress has been made in understanding the mechanism of action (MoA) of artemisinin. Prior research on the MoA of artemisinin mainly focused on covalently bound targets that are alkylated by artemisinin free radicals. However, less attention has been given to the reversible noncovalent binding targets and there is a paucity of information regarding artemisinin targets at different life cycle stages of the parasite. In this study, we identified the protein targets of artemisinin at different stages of the parasite's intraerythrocytic developmental cycle using a photoaffinity probe. |
| Sample scope |
Multiisolate |
| Release date |
2024-03-03 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Photoaffinity probe‐based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of Plasmodium falciparum
|
iMeta
|
10.1002/imt2.176
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82141001
|
|
|
|
| Submitter |
WANG
CHEN (cwang1992@icmm.ac.cn)
|
| Organization |
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences |
| Submission date |
2024-01-17 |
