| 项目编号 |
PRJCA022926 |
| 项目标题 |
Photoaffinity probe-based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of Plasmodium falciparum |
| 涉及领域 |
Model organism |
| 数据类型 |
Phenotype or Genotype
|
| 物种名称 |
Plasmodium falciparum 3D7
|
| 描述信息 |
Malaria continues to pose a serious global health threat, and artemisinin remains the core drug for global malaria control. However, the situation of malaria resistance has become increasingly severe due to the emergence and spread of artemisinin resistance. In recent years, significant progress has been made in understanding the mechanism of action (MoA) of artemisinin. Prior research on the MoA of artemisinin mainly focused on covalently bound targets that are alkylated by artemisinin free radicals. However, less attention has been given to the reversible noncovalent binding targets and there is a paucity of information regarding artemisinin targets at different life cycle stages of the parasite. In this study, we identified the protein targets of artemisinin at different stages of the parasite's intraerythrocytic developmental cycle using a photoaffinity probe. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-03-03 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Photoaffinity probe‐based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of Plasmodium falciparum
|
iMeta
|
10.1002/imt2.176
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82141001
|
|
|
|
| 提交者 |
WANG
CHEN (cwang1992@icmm.ac.cn)
|
| 提交单位 |
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences |
| 提交日期 |
2024-01-17 |
