| Accession |
PRJCA022934 |
| Title |
PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumour immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
In the current study, we sought to figure out the expression pattern and biological role of PREX2 in the radioresistance of CRC. We found that the overexpression of PREX2 significantly weakened radiotherapy sensitivity in vitro and in vivo. Moreover, PREX2 promoted DNA double-strand break repair by upregulating DNA-PKcs and inhibiting radiation-induced immunogenic cell death and CD8+ T cell infiltration through the cGAS/STING/IFNs pathway. Targeting PREX2 with the small molecule PREX-in1 significantly sensitized the efficacy of CRC IR therapy and enhanced CD8+ T cell infiltration. Our data demonstrated that PREX2 acts as a novel biomarker for CRC sensitive to preoperative radiotherapy and a therapeutic target in radiotherapy-resistant CRC patients. |
| Sample scope |
Monoisolate |
| Release date |
2024-01-23 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38609982
|
PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer
|
BMC Medicine
|
10.1186/s12916-024-03375-2
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
No.82273358
|
|
|
|
| Submitter |
li
liang (redsnow007@126.com)
|
| Organization |
Southern Medical University |
| Submission date |
2024-01-17 |
