| Accession |
PRJCA022942 |
| Title |
Fused in sarcoma (FUS) inhibits milk production efficiency in mammals |
| Relevance |
Evolution development |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
Petaurus breviceps
|
| Description |
Efficient milk secretion in mammals confers evolutionary advantages by facilitating the transmission of energy from mother to offspring. However, the regulatory mechanism responsible for the gradual establishment of milk secretion efficiency in mammals, from marsupials to eutherians, remains elusive. Here, we find that mammary gland of the marsupial sugar glider contained milk components during adolescence, and that mammary gland development is less dynamically cyclic compared to that in placental mammals. Furthermore, fused in sarcoma (FUS) is found to be partially responsible for this establishment of low efficiency. In mouse model, FUS inhibit mammary epithelial cell differentiation through the cyclin-dependent kinase inhibitor p57Kip2, leading to lactation failure and pup starvation. Clinically, FUS levels are negatively correlated with milk production in lactating women. Overall, our results shed light on FUS as a negative regulator of milk production, providing a potential mechanism for the establishment of milk secretion from marsupial to eutherian mammals. |
| Sample scope |
Multiisolate |
| Release date |
2024-01-18 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| the National Key Research and Development Program of China
|
|
2023YFA1800500
|
|
| National Natural Science Foundation of China
|
|
U23A20452
|
|
| Yunnan Applied Basic Research Key Projects
|
|
202301AT070280
|
|
| Spring City Project from Kunming Science and Technology Bureau
|
|
2022SCP007
|
|
|
|
| Submitter |
baowei
jiao (jiaobaowei@mail.kiz.ac.cn)
|
| Organization |
Chinese Academy of Sciences |
| Submission date |
2024-01-18 |
